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Test Code SUPRA Supersaturation Profile, Random, Urine


Ordering Guidance


A timed 24-hour urine collection is the preferred specimen for measuring and interpreting this profile to determine kidney stone risk factors (SUP24 / Supersaturation Profile, 24 Hour, Urine). Random urine collections with individual analytes normalized to urinary creatinine may be of some clinical use in patients who cannot collect a 24-hour specimen, typically small children. Therefore, this test is offered on random collections for children less than 16 years old.

 

X-ray dyes and contrast media will affect uric acid test results.

-If a kidney X-ray with dye or computerized tomography (CT) scan with contrast has been performed, patient should wait a minimum of 1 day before starting collection.

-If a cholangiography (bile duct X-ray) has performed, patient should wait 7 days before starting collection.

-Urine must be collected before tablets have been taken for gallbladder X-ray, otherwise patient should wait 7 days before starting collection.



Necessary Information


Patient's age is required.



Specimen Required


Supplies:

-Urine Tubes, 10 mL (T068)

-Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: 90 mL urine container

Submission Container/Tube: 2 x 10 mL plastic urine tubes and 5 x 5 mL plastic urine tubes

Specimen Volume: 40 mL

Collection Instructions:

1. Collect a random urine specimen, mix collection container thoroughly and divide the urine into 7 plastic tubes (2 x 10 mL and 5 x 5 mL).

2. Refrigerate specimen after collection. Specimen pH should be between 4.5 and 8 and will stay in this range if kept refrigerated. Specimens with pH above 8 indicate bacterial contamination, and testing will be canceled. Do not attempt to adjust pH as it will adversely affect results.


Useful For

Diagnosis and management of patients with renal lithiasis:

-Predicting the likely composition of the stone, in patients who have a radiopaque stone, for whom stone analysis is not available which may help in designing a treatment program

-Identifying specific risk factors for stones formation using a random urine collection

-Monitoring the effectiveness of therapy by confirming that the crystallization potential has indeed decreased

-Evaluation of kidney excretion of acid and urine pH

Profile Information

Test ID Reporting Name Available Separately Always Performed
SRINT Supersaturation, Random, U 1 No Yes
RANAU Sodium, Random, U Yes, (order RNAUR) Yes
RAKUR Potassium, Random, U Yes, (order RKUR) Yes
RACAL Calcium, Random, U Yes, (order CACR3) Yes
RAMAG Magnesium, Random, U Yes, (order MAGRU) Yes
RACLU Chloride, Random, U Yes, (order RCHLU) Yes
RAPOU Phosphorus, Random, U Yes, (order RPHOC) Yes
RASUL Sulfate, Random, U No Yes
RACIT Citrate Excretion, Random, U Yes, (order CITRA) Yes
RAOXU Oxalate, Random, U Yes, (order ROXUR) Yes
RAPHU pH, Random, U No Yes
RAURA Uric Acid, Random, U Yes, (order RURC1) Yes
RACTU Creatinine, Random, U Yes, (order RCTUR) Yes
RAOSM Osmolality, Random, U No Yes
RAAMM Ammonium, Random, U Yes, (order RAMBO) Yes

Method Name

RACIT, RAAMM, RAOXU: Enzymatic

RAOSM: Freezing Point Depression

RASUL: High-Performance Ion Chromatography (HPIC)

RAMAG: Colorimetric Endpoint Assay

RACAL, RAPOU: Photometric

RAPHU: pH Meter

RANAU, RAKUR, RACLU: Potentiometric, Indirect Ion-Selective Electrode (ISE)

RACTU: Enzymatic Colorimetric Assay

RAURA: Uricase

Reporting Name

Supersaturation, Random, U

Specimen Type

Urine

Specimen Minimum Volume

30 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  72 hours

Reject Due To

pH <4.5 or >8.0 Reject

Reference Values

The following analytes do not have any established reference values:

Sodium, potassium, chloride, phosphorus, citrate, sulfate, and oxalate

pH: 4.5-8.0

 

CREATININE

≥18 years old: 16-326 mg/dL

Reference values have not been established for patients who are younger than 18 years.

 

OSMOLALITY

0-11 months: 50-750 mOsm/kg

≥12 months: 150-1,150 mOsm/kg

 

AMMONIUM

18-77 years: 3-65 mmol/L

No reference values established for patients who are younger than 18 years or older than 77 years.

 

CALCIUM

1 month-<12 months: 0.03-0.81 mg/mg creat

12 months-<24 months: 0.03-0.56 mg/mg creat

24 months-<3 years: 0.02-0.50 mg/mg creat

3 years-<5 years: 0.02-0.41 mg/mg creat

5 years-<7 years: 0.01-0.30 mg/mg creat

7 years-<10 years: 0.01-0.25 mg/mg creat

10 years-<18 years: 0.01-0.24 mg/mg creat

18 years-83 years: 0.05-0.27 mg/mg creat

Reference values have not been established for patients who are younger than 1 month or older than 83 years.

 

MAGNESIUM

Magnesium/Creatinine Ratio:

1 month-<12 months: 0.10-0.48 mg/mg creat

12 months-<24 months: 0.09-0.37 mg/mg creat

24 months-<3 years: 0.07-0.34 mg/mg creat

3 years-<5 years: 0.07-0.29 mg/mg creat

5 years-<7 years: 0.06-0.21 mg/mg creat

7 years-<10 years: 0.05-0.18 mg/mg creat

10 years-<14 years: 0.05-0.15 mg/mg creat

14 years-<18 years: 0.05-0.13 mg/mg creat

18 years-83 years: 0.04-0.12 mg/mg creat

Reference values have not been established for patients who are younger than 1 month or older than 83 years.

Day(s) Performed

Monday through Sunday

Report Available

2 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82310-Calcium

82436-Chloride

82507-Citrate excretion

82570-Creatinine

83735-Magnesium

83935-Osmolality

83945-Oxalate

83986-pH

84105-Phosphorus

84133-Potassium

84300-Sodium

84392-Sulfate

84560-Uric acid

82140-Ammonium

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SUPRA Supersaturation, Random, U 101929-8

 

Result ID Test Result Name Result LOINC Value
RASUC Sulfate, Random, U 2975-1
RAPHU pH, Random, U 2756-5
RAOSU Osmolality, Random, U 2695-5
RANAC Sodium, Random, U 2955-3
RACTU Creatinine, Random, U 2161-8
RAKUC Potassium, Random, U 2828-2
RACLC Chloride, Random, U 2078-4
RAAMM Ammonium, Random, U 1842-4
RACAC Calcium, Random, U 17862-4
CITCO Citrate Excretion, Random, U 2128-7
RAMGC Magnesium, Random, U 19124-7
POUCO Phosphorus, Random, U 2778-9
RAUAC Uric Acid, Random, U 3086-6
OXMCO Oxalate, Random, U (mmol/L) 15086-2
616399 Calcium Oxalate Crystal In Process
616400 Brushite Crystal In Process
OXGCO Oxalate, Random, U (mg/L) 2700-3
UACCR Uric Acid/Creat Ratio, Random, U 3089-0
PHOCR Phosphorus/Creat Ratio, Random, U 11141-9
MAGCR Magnesium/Creat Ratio, Random, U 13474-2
CITCR Citrate/Creatinine Ratio, Random, U 13722-4
CALCR Calcium/Creatinine Ratio, Random, U 9321-1
OXUCR Oxalate/Creatinine Ratio, Random, U 13483-3
616401 Hydroxyapatite Crystal In Process
616402 Uric Acid Crystal In Process
31246 Interpretation 69051-1